Key Publications of Java Clinical staff and consulting scientists

Java Publications

  • Fitzgerald, D. J., & FitzGerald, G. A. (2013). Historical Lessons in Translational Medicine Cyclooxygenase Inhibition and P2Y12 Antagonism. Circulation Research, 112(1), 174-194. | Pubmed | Download PDF |
  • Wiviott, S. D., Flather, M. D., O’Donoghue, M. L., Goto, S., Fitzgerald, D. J., Cura, F., … & Bhatt, D. L. (2011). Randomized Trial of Atopaxar in the Treatment of Patients With Coronary Artery Disease The Lessons From Antagonizing the Cellular Effect of Thrombin–Coronary Artery Disease Trial. Circulation, 123(17), 1854-1863. | Pubmed | Download PDF |
  • McRedmond, J. (2011). Platelet Aggregation Quality Control in a Multicenter, Phase 2 Clinical Trial. Drug Information Journal, 45(6), 731-740. | Download PDF |
  • McRedmond, J. (2010). Dynamic Data. International Clinical Trials, 13, 32-37. | Download PDF |

Prof Des Fitzgerald

  • Belton, O., Byrne, D., Kearney, D., Leahy, A., & Fitzgerald, D. J. (2000). Cyclooxygenase-1 and-2–dependent prostacyclin formation in patients with atherosclerosis. Circulation, 102(8), 840-845. | Pubmed | Download PDF |
  • Dowd, N. P., Scully, M., Adderley, S. R., Cunningham, A. J., & Fitzgerald, D. J. (2001). Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. Journal of Clinical Investigation, 108(4), 585. | Pubmed | Download PDF |
  • Fitzgerald, D. J., Wright, F., & FitzGerald, G. A. (1989). Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo. Circulation Research, 65(1), 83-94. | Pubmed | Download PDF |
  • Sheehan, K. M., Sheahan, K., O’Donoghue, D. P., MacSweeney, F., Conroy, R. M., Fitzgerald, D. J., & Murray, F. E. (1999). The relationship between cyclooxygenase-2 expression and colorectal cancer. JAMA, 282(13), 1254-1257. | Pubmed | Download PDF |

Dr James McRedmond

  • Power, K. A., McRedmond, J. P., de Stefani, A., Gallagher, W. M., & Gaora, P. O. (2009). High-throughput proteomics detection of novel splice isoforms in human platelets. PLOS ONE, 4(3), e5001. | Pubmed | Download PDF |
  • Wong, J. W., McRedmond, J. P., & Cagney, G. (2009). Activity profiling of platelets by chemical proteomics. Proteomics, 9(1), 40-50. | Pubmed |
  • McRedmond, J. P., Park, S. D., Reilly, D. F., Coppinger, J. A., Maguire, P. B., Shields, D. C., & Fitzgerald, D. J. (2004). Integration of Proteomics and Genomics in Platelets – a profile of platelet proteins and platelet-specific genes. Molecular & Cellular Proteomics, 3(2), 133-144. | Pubmed | Download PDF |
  • Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., … & Maguire, P. B. (2004). Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103(6), 2096-2104. | Pubmed | Download PDF |
  • McRedmond, J. P., Harriott, P., Walker, B., & Fitzgerald, D. J. (2000). Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Blood, 95(4), 1301-1308. | Pubmed | Download PDF |

White Papers

  • Patrono, C., Bachmann, F., Baigent, C., Bode, C., De Caterina, R., Charbonnier, B., … & Wilcox, R. (2004). Expert consensus document on the use of antiplatelet agents The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European Society of Cardiology. European Heart Journal, 25(2), 166-181. | Pubmed | Download PDF |
  • O’Brien, E. (2011). 24-hour blood pressure monitoring: its efficacy and techniques. Hot Topics in Hypertension, 4(12), 7-23.  | Download PDF |

Dr Orina Belton

  • Marcantoni, E., Dovizio, M., Peadar, O., Di Francesco, L., Bendaya, I., Schiavone, S., … & Belton, O. (2015). Dysregulation of gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-β1. | Pubmed |
  • de Gaetano, M., Alghamdi, K., Marcone, S., & Belton, O. (2015). Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation. Journal of Inflammation, 12(1), 15. | Pubmed |
  • de Gaetano, M., Dempsey, E., Marcone, S., James, W. G., & Belton, O. (2013). Conjugated Linoleic Acid Targets β2 Integrin Expression To Suppress Monocyte Adhesion. The Journal of Immunology, 191(8), 4326-4336. | Pubmed |
  • McCarthy, C., Lieggi, N. T., Barry, D., Mooney, D., de Gaetano, M., James, W. G., … & Belton, O. (2013). Macrophage PPAR gamma Co‐activator‐1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid. EMBO Molecular Medicine, 5(9), 1443-1457. | Pubmed |
  • McCarthy, C., Duffy, M. M., Mooney, D., James, W. G., Griffin, M. D., Fitzgerald, D. J., & Belton, O. (2013). IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis. The FASEB Journal, 27(2), 499-510. | Pubmed |

Dr Alfonso Blanco

  • Dobrzyński, M., Nguyen, L. K., Birtwistle, M. R., von Kriegsheim, A., Blanco Fernández, A., Cheong, A., … & Kholodenko, B. N. (2014). Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses. Journal of The Royal Society Interface, 11(98), 20140383. | Pubmed |
  • Arnoldini, M., Heck, T., Blanco-Fernández, A., & Hammes, F. (2013). Monitoring of dynamic microbiological processes using real-time flow cytometry. PLOS ONE, 8(11), e80117. | Pubmed |
  • Gegenbauer, K., Elia, G., Blanco-Fernandez, A., & Smolenski, A. (2012). Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets. Blood, 119(16), 3799-3807. | Pubmed |
  • Saldova, R., Dempsey, E., Pérez-Garay, M., Mariño, K., Watson, J. A., Blanco-Fernández, A., … & Rudd, P. M. (2011). 5-AZA-2′-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer. Epigenetics, 6(11), 1362-1372. | Pubmed |
  • Vines, A., McBean, G. J., & Blanco‐Fernández, A. (2010). A flow‐cytometric method for continuous measurement of intracellular Ca2+ concentration. Cytometry Part A, 77(11), 1091-1097. | Pubmed |

Dr Patricia Maguire

  • Macaulay, I. C., Thon, J. N., Tijssen, M. R., Steele, B. M., MacDonald, B. T., Meade, G., … & Maguire, P. B. (2013). Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood, 121(1), 188-196. | Pubmed |
  • Steele, B. M., Harper, M. T., Smolenski, A. P., Alkazemi, N., Poole, A. W., Fitzgerald, D. J., & Maguire, P. B. (2012). WNT-3a modulates platelet function by regulating small GTPase activity. FEBS Letters, 586(16), 2267-2272. | Pubmed |
  • Goodall, A. H., Burns, P., Salles, I., Macaulay, I. C., Jones, C. I., Ardissino, D., … & Ouwehand, W. H. (2010). Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood, 116(22), 4646-4656. | Pubmed |
  • Steele, B. M., Harper, M. T., Macaulay, I. C., Morrell, C. N., Perez-Tamayo, A., Foy, M., … & Maguire, P. B. (2009). Canonical Wnt signaling negatively regulates platelet function. Proceedings of the National Academy of Sciences, 106(47), 19836-19841. | Pubmed |
  • Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., … & Maguire, P. B. (2004). Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103(6), 2096-2104. | Pubmed |

Dr Ronan Murphy

  • Martin, F. A., McLoughlin, A., Rochfort, K. D., Davenport, C., Murphy, R. P., & Cummins, P. M. (2014). Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain. PLOS ONE, 9(9), e108254. | Pubmed |
  • Guinan, A. F., Rochfort, K. D., Fitzpatrick, P. A., Walsh, T. G., Pierotti, A. R., Phelan, S., … & Cummins, P. M. (2013). Shear stress is a positive regulator of thimet oligopeptidase (EC3. 4.24. 15) in vascular endothelial cells: consequences for MHC1 levels. Cardiovascular Research, cvt127. | Pubmed |
  • Harrison, M., Murphy, R. P., O’Connor, P. L., O’Gorman, D. J., McCaffrey, N., Cummins, P. M., & Moyna, N. M. (2009). The endothelial microparticle response to a high fat meal is not attenuated by prior exercise. European Journal of Applied Physiology, 106(4), 555-562. | Pubmed |
  • Kerrigan, S. W., Gaur, M., Murphy, R. P., Shattil, S. J., & Leavitt, A. D. (2004). Caspase-12: a developmental link between G-protein–coupled receptors and integrin αIIbβ3 activation. Blood, 104(5), 1327-1334. | Pubmed |
  • Eto, K., Murphy, R., Kerrigan, S. W., Bertoni, A., Stuhlmann, H., Nakano, T., … & Shattil, S. J. (2002). Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proceedings of the National Academy of Sciences, 99(20), 12819-12824. | Pubmed |

Dr Albert Smolenski

  • Hampson, A., O’Connor, A., & Smolenski, A. (2013). Synaptotagmin‐like protein 4 and Rab8 interact and increase dense granule release in platelets. Journal of Thrombosis and Haemostasis, 11(1), 161-168. | Pubmed |
  • Gegenbauer, K., Elia, G., Blanco-Fernandez, A., & Smolenski, A. (2012). Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets. Blood, 119(16), 3799-3807. | Pubmed |
  • Neumüller, O., Hoffmeister, M., Babica, J., Prelle, C., Gegenbauer, K., & Smolenski, A. P. (2009). Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood, 114(7), 1396-1404. | Pubmed |
  • Schultess, J., Danielewski, O., & Smolenski, A. P. (2005). Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood, 105(8), 3185-3192. | Pubmed |
  • Smolenski, A., Bachmann, C., Reinhard, K., Hönig-Liedl, P., Jarchau, T., Hoschuetzky, H., & Walter, U. (1998). Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody. Journal of Biological Chemistry, 273(32), 20029-20035. | Pubmed |