Prof Des Fitzgerald
COX1 & 2 in atherosclerosis
Demonstrated the role of COX-1 and COX-2 in the production of prostacyclin and thromboxane in atherosclerosis, with implications for the use of selective COX-2 inhibitors.
COX2 protects heart from doxirubicin
Showed that cardiotoxicity, a crucial side effect of the anticancer drug doxorubicin, is exacerbated by inhibition of COX2.
t-PA treatment activates platelets
Proved that treatment of myocardial infarction with t-PA also causes platelet activation, warranting co-treatment with aspirin.
COX2 & colorectal cancer
Demonstrated that COX2 has a protective effect in colorectal cancer.