Prof Des Fitzgerald

Prof Des Fitzgerald

 

Download PDF COX1 & 2 in atherosclerosis
Demonstrated the role of COX-1 and COX-2 in the production of prostacyclin and thromboxane in atherosclerosis, with implications for the use of selective COX-2 inhibitors.

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Download PDF COX2 protects heart from doxirubicin
Showed that cardiotoxicity, a crucial side effect of the anticancer drug doxorubicin, is exacerbated by inhibition of COX2.

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Download PDF t-PA treatment activates platelets
Proved that treatment of myocardial infarction with t-PA also causes platelet activation, warranting co-treatment with aspirin.

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Download PDF COX2 & colorectal cancer
Demonstrated that COX2 has a protective effect in colorectal cancer.

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