Dr Ronan Murphy

Dr Ronan Murphy

Dr Ronan Murphy is a Lecturer in Cell & Molecular Physiology in the School of Health and Human Performance at Dublin City University and Vice Chair for Epigenetic Technologies in the European Cooperation in Science and Technology (COST) initiative – Action CM1406 Epigenetic Chemical Biology (EPICHEM).

Dr Murphy’s research interests include integrin signalling, regulation of cellular interactions by haemodynamics, cell biology of platelets and megakaryocytes, the development of cardiovascular diagnostics, space medicine and epigenetics.
He uses technologies including dynamic cell interaction measurement, microRNA and microvesicle analysis, and organotypic multi-culture technologies to model complex biological systems in vitro and measure the effects of disease states, stresses and treatments.

Dr Murphy works with Java Clinical on analysis of stem cells in clinical trials; transcriptional analysis and microparticle analysis in clinical trials, and preclinical modelling of complex systems.

Key Publications

Martin, F. A., McLoughlin, A., Rochfort, K. D., Davenport, C., Murphy, R. P., & Cummins, P. M. (2014). Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain. PLOS ONE, 9(9), e108254. | Pubmed |

Guinan, A. F., Rochfort, K. D., Fitzpatrick, P. A., Walsh, T. G., Pierotti, A. R., Phelan, S., … & Cummins, P. M. (2013). Shear stress is a positive regulator of thimet oligopeptidase (EC3. 4.24. 15) in vascular endothelial cells: consequences for MHC1 levels. Cardiovascular Research, cvt127. | Pubmed |

Harrison, M., Murphy, R. P., O’Connor, P. L., O’Gorman, D. J., McCaffrey, N., Cummins, P. M., & Moyna, N. M. (2009). The endothelial microparticle response to a high fat meal is not attenuated by prior exercise. European Journal of Applied Physiology, 106(4), 555-562. | Pubmed |

Kerrigan, S. W., Gaur, M., Murphy, R. P., Shattil, S. J., & Leavitt, A. D. (2004). Caspase-12: a developmental link between G-protein–coupled receptors and integrin αIIbβ3 activation. Blood, 104(5), 1327-1334. | Pubmed |

Eto, K., Murphy, R., Kerrigan, S. W., Bertoni, A., Stuhlmann, H., Nakano, T., … & Shattil, S. J. (2002). Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proceedings of the National Academy of Sciences, 99(20), 12819-12824. | Pubmed |