Dr Patricia Maguire
Dr Maguire’s research interests are in transcriptional and proteomic analysis and the dissection of Wnt pathways in platelets and the cardiovascular system.
She combines classical cell biology approaches and proteomic analysis to delineate novel biochemical pathways in platelets, including discovery of platelet Wnt signalling and its role in thrombotic responses as well as novel platelet functions.
Dr Maguire works with Java Clinical on biochemical analyses and a Java Research and Development project exploring platelet biomarkers using proteomic analysis of clinical samples.
Macaulay, I. C., Thon, J. N., Tijssen, M. R., Steele, B. M., MacDonald, B. T., Meade, G., … & Maguire, P. B. (2013). Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood, 121(1), 188-196. | Pubmed |
Steele, B. M., Harper, M. T., Smolenski, A. P., Alkazemi, N., Poole, A. W., Fitzgerald, D. J., & Maguire, P. B. (2012). WNT-3a modulates platelet function by regulating small GTPase activity. FEBS Letters, 586(16), 2267-2272. | Pubmed |
Goodall, A. H., Burns, P., Salles, I., Macaulay, I. C., Jones, C. I., Ardissino, D., … & Ouwehand, W. H. (2010). Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood, 116(22), 4646-4656. | Pubmed |
Steele, B. M., Harper, M. T., Macaulay, I. C., Morrell, C. N., Perez-Tamayo, A., Foy, M., … & Maguire, P. B. (2009). Canonical Wnt signaling negatively regulates platelet function. Proceedings of the National Academy of Sciences, 106(47), 19836-19841. | Pubmed |
Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., … & Maguire, P. B. (2004). Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103(6), 2096-2104. | Pubmed |